Guvacine hydrochloride ( —— )

产品货号. M20972 CAS No. 6027-91-4

COA

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HNMR

HPLC

MSDS

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产品名称

Guvacine hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GuvacineHClide 是一种 GABA 摄取抑制剂（IC50：10 μM）。
产品描述

Guvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).
体外实验

Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

GABA
研究领域

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适应症

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1.Johnston G A R Krogsgaard-Larsen P Stephanson A . Betel nut constituents as inhibitors of γ-aminobutyric acid uptake[J]. Nature.

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